Tesofensine
ResearchA triple monoamine reuptake inhibitor originally researched for Parkinson's and Alzheimer's. Repurposed for obesity research showing significant weight loss in trials.
Weight ManagementCognitive Enhancement
Half Life
~220 hours
Time to Results
4-12 weeks
Administration
Oral
🐾 Griffin's Research Scorecard
Research Strength
Human Data
Animal Data
Long-Term Data
Beginner Friendly
Storage Difficulty
Injection FrequencyDaily (oral)
Cost$$$
🐾 Griffin Says...
Not technically a peptide but commonly researched alongside weight management peptides. Phase 2 trials showed around 10% weight loss at 0.5mg dose over 24 weeks. Cardiovascular monitoring is important given its mechanism.
Benefits
- Significant weight loss in trials
- Appetite suppression
- Increased energy expenditure
- Cognitive function research
Best For
- Weight loss research
- Metabolic health
Body Systems
MetabolicNervous System
Mechanisms of Action
- Inhibits reuptake of serotonin, norepinephrine, and dopamine
- Reduces appetite via CNS mechanisms
- Increases metabolic rate
Side Effects
| Effect | Frequency | Severity |
|---|---|---|
| Increased heart rate | Common | Moderate |
| Dry mouth | Common | Mild |
| Insomnia | Common | Mild |
| Nausea | Common | Mild |
Contraindications
Cardiovascular disease, hypertension, MAOI medications, psychiatric conditions
Peptides discussed here are for research purposes only. Nothing on this page is medical advice. Always consult a qualified professional before making health decisions.
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