Semaglutide
FDA ApprovedA GLP-1 receptor agonist approved for type 2 diabetes and chronic weight management.
MetabolicWeight Management
Half Life
~1 week
Time to Results
4-8 weeks
Administration
Subcutaneous injection, Oral tablet
🐾 Griffin's Research Scorecard
Research Strength
Human Data
Animal Data
Long-Term Data
Beginner Friendly
Storage Difficulty
Injection FrequencyWeekly
Cost$$$
🐾 Griffin Says...
The most clinically validated peptide in this library. Titrate slowly -- most side effects come from ramping the dose too fast.
Benefits
- Appetite regulation
- Blood glucose control
- Sustained fat loss
Best For
- Weight loss
- Type 2 diabetes support
Body Systems
EndocrineDigestive
How It Works
Semaglutide mimics glucagon-like peptide-1 to improve blood sugar control, slow gastric emptying, and reduce appetite. It has been extensively studied in humans.
Mechanisms of Action
- GLP-1 receptor agonism
- Delayed gastric emptying
Side Effects
| Effect | Frequency | Severity |
|---|---|---|
| Nausea | Common | Mild to moderate |
| Constipation | Common | Mild |
| Pancreatitis | Rare | Severe |
Contraindications
Personal or family history of medullary thyroid carcinoma; MEN 2.
Peptides discussed here are for research purposes only. Nothing on this page is medical advice. Always consult a qualified professional before making health decisions.
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