Selank Amidate
Preclinical ResearchSelank Amidate
An amidated version of Selank with potentially improved stability and bioavailability. Same anxiolytic and cognitive benefits with modifications for enhanced delivery.
Dose
0.5 mg - 3 mg
Route
Nasal spray, SubQ injection
Cycle
10-20 days
Storage
2°C to 8°C (refrigerator)
What is Selank Amidate?
Selank Amidate is a synthetic analog of the naturally occurring immunomodulatory peptide tuftsin, with an amidated C-terminus designed to enhance stability and bioavailability compared to the non-amidated Selank. It is commonly discussed in research contexts for its anxiolytic, nootropic, and neuroprotective properties. Its mechanism of action is thought to involve modulation of the GABAergic system, influencing the balance of monoamine neurotransmitters, and affecting the expression of brain-derived neurotrophic factor (BDNF). The amidation is hypothesized to reduce enzymatic degradation, leading to a prolonged half-life and potentially more consistent effects.
Key Benefits
- Anxiety reduction
- Mood stabilization
- Cognitive support
- Improved bioavailability vs Selank
Mechanism of Action
- Amidated Selank structure for stability
- GABA and serotonin modulation
- Crosses blood-brain barrier
Best For
- Anxiety research
- Cognitive performance
Body Systems
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Molecular Information
Molecular weight
775.87 g/mol
Length
7
Type
Heptapeptide Amide
Amino acid sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2
Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) represents the Selank sequence. The -NH2 indicates amidation at the C-terminus.
Research Indications
Generalized Anxiety Disorder (GAD)
Research indicates potential for reducing symptoms of anxiety and improving emotional regulation.
Stress Response Modulation
Studies suggest it may mitigate the physiological and psychological effects of chronic stress.
Research Protocols
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General Anxiolytic Effects (SubQ) | 0.5 mg - 1.5 mg | 1-2 times daily | Subcutaneous injection |
| General Anxiolytic Effects (Nasal) | 0.5 mg - 1.5 mg per nostril | 1-2 times daily | Nasal spray |
| Cognitive Enhancement (SubQ) | 1.0 mg - 2.0 mg | 1-2 times daily | Subcutaneous injection |
| Cognitive Enhancement (Nasal) | 1.0 mg - 2.0 mg per nostril | 1-2 times daily | Nasal spray |
| Intensive Protocol for Severe Stress/Anxiety (SubQ) | 2.0 mg - 3.0 mg | 1-2 times daily | Subcutaneous injection |
For nasal administration, doses are typically divided across the day. For subcutaneous injection, consistent daily timing is often discussed to maintain stable levels.
Peptide Interactions
- Monitor Combination
Benzodiazepines
Both compounds affect GABAergic systems. Concurrent use may lead to excessive sedation or other CNS depression; caution advised in research.
- Use Caution
Alcohol
Alcohol is a CNS depressant. Combining with Selank Amidate may exacerbate sedative effects. Avoid or use with extreme caution in research.
- Monitor Combination
SSRIs/SNRIs
Selank Amidate may influence serotonin and other monoamine neurotransmitters. Concurrent use with antidepressants warrants careful observation for additive or unexpected effects in research.
- Compatible
Nootropics (e.g., Piracetam)
Some research suggests complementary effects with other cognitive enhancers, potentially leading to synergistic improvements in cognitive function. Monitor individual responses.
- Monitor Combination
Caffeine/Stimulants
May counteract the anxiolytic effects of Selank Amidate or lead to an imbalanced state. Observe individual responses in research settings.
How to Reconstitute
- 1Gather materials: lyophilized Selank Amidate vial, sterile bacteriostatic water, sterile syringe, and alcohol wipes.
- 2Remove the cap from the Selank Amidate vial and wipe the rubber stopper with an alcohol wipe.
- 3Draw the desired amount of bacteriostatic water into the sterile syringe. A common ratio is 1ml of bacteriostatic water per 5mg vial of Selank Amidate for a concentration of 5mg/ml.
- 4Slowly inject the bacteriostatic water down the side of the vial, allowing it to gently mix with the lyophilized powder. Do not inject directly onto the powder.
- 5Remove the syringe and gently swirl the vial for several minutes until the powder is completely dissolved. Do not shake.
- 6Once dissolved, store the reconstituted solution in the refrigerator. Use within 20-30 days.
Accurate measurement of bacteriostatic water is crucial for precise dosing. Avoid shaking the vial vigorously to prevent peptide degradation.
What to Expect
- Weeks 1-2: Initial anxiolytic effects and subtle mood improvements may be observed in some research subjects.
- Weeks 2-4: More consistent reports of reduced anxiety, improved stress resilience, and potential cognitive benefits (e.g., focus, memory) in ongoing studies.
- Weeks 4-6: Peak effects for mood stabilization and cognitive enhancement are often discussed, with sustained benefits during this period.
- Post-cycle: Anecdotal reports in research contexts suggest a 'carry-over' effect of improved mood and cognitive function even after cessation, though further study is needed.
Side Effects & Safety
| Effect | Frequency | Severity |
|---|---|---|
| Minimal | Rare | Mild |
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