Selank
Human ResearchSelank
A synthetic analog of tuftsin, Selank is an anxiolytic peptide approved in Russia. Researched for anxiety reduction, cognitive enhancement, and mood stabilization.
Dose
250 mcg - 500 mcg
Route
Nasal spray, SubQ injection
Cycle
10-14 days
Storage
Refrigerated (2°C to 8°C) or frozen (-20°C or colder) away from light.
What is Selank?
Selank is a synthetic heptapeptide, an analog of the endogenous immunomodulatory peptide tuftsin. It is widely discussed in research for its potential anxiolytic, antidepressant, and nootropic effects. In Russia, it has been approved as an anxiolytic medication. Research suggests that Selank can modulate the expression of brain-derived neurotrophic factor (BDNF), influence monoaminergic systems, and interact with GABAergic neurotransmission. It is known to cross the blood-brain barrier. Common research administration methods include subcutaneous injection and nasal spray, with nasal administration being popular due to its non-invasive nature and rapid absorption.
Key Benefits
- Anxiety reduction
- Improved focus
- Memory enhancement
- Mood stabilization
- Anti-stress effects
- No sedation
Mechanism of Action
- Acts on opioid, serotonergic, and GABA pathways
- Crosses blood-brain barrier
- Modulates BDNF expression
Best For
- Anxiety research
- Cognitive performance research
- Stress management
Body Systems
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Molecular Information
Molecular weight
751.8 g/mol
Length
7 amino acids
Type
Heptapeptide
Amino acid sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Commonly written as Thr-Lys-Pro-Arg-Pro-Gly-Pro. (Threonine-Lysine-Proline-Arginine-Proline-Glycine-Proline)
Pharmacokinetics
Time to peak
10-30 minutes (nasal)
Half-life
0.05 h
Time to clear
Approximately 30 minutes (nasal)
Literature commonly reports a very short half-life due to rapid enzymatic degradation.
Research Indications
Anxiety Reduction
Widely researched for its anxiolytic properties, with studies suggesting efficacy in generalized anxiety and stress-induced anxiety conditions.
Mood Stabilization
Research indicates potential for improving mood and reducing symptoms associated with depression and emotional dysregulation.
Research Protocols
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General Anxiolysis & Mood Support | 250 mcg | 2 times daily | Subcutaneous or Nasal |
| Enhanced Cognitive Function & Focus | 500 mcg | 2 times daily | Subcutaneous or Nasal |
| Acute Stress Response Management | 500 mcg | As needed (up to 3 times daily) | Subcutaneous or Nasal |
| Adjunct for Learning & Memory Tasks | 250 mcg - 500 mcg | Once daily, 30-60 minutes before tasks | Nasal |
| Intensive Anxiolysis | 500 mcg | 3 times daily | Subcutaneous |
Due to its short half-life, multiple daily administrations are commonly discussed in research to maintain consistent levels.
Peptide Interactions
- Monitor Combination
Benzodiazepines (e.g., Alprazolam, Diazepam)
Selank is reported to act on GABAergic systems. While not reported to cause sedation, caution and monitoring for synergistic sedative effects are advisable, especially with higher doses of both.
- Monitor Combination
SSRIs (Selective Serotonin Reuptake Inhibitors)
Selank can influence serotonergic pathways. Monitor for potential additive effects on mood or anxiety, though specific negative interactions are not widely reported in research.
- Use Caution
Alcohol
Although not directly studied, combining Selank with alcohol may lead to unpredictable effects, especially given its influence on CNS function. General caution is advised.
- Compatible
Nootropics (e.g., Piracetam, Noopept)
Often discussed in research as a complementary agent for cognitive enhancement. No widely reported negative interactions; potential for synergistic cognitive benefits.
- Monitor Combination
Opioid Analgesics
As a tuftsin analog, Selank interacts with opioid receptors. While not an opioid itself, concurrent use with opioid analgesics should be monitored for any altered effects.
How to Reconstitute
- 1Gather lyophilized Selank vial, bacteriostatic water (BWFI), sterile syringes, and alcohol wipes.
- 2Clean the rubber stopper of both the Selank vial and the BWFI vial with alcohol wipes.
- 3Draw the desired amount of BWFI into a sterile syringe. A common ratio is 1ml of BWFI per 10mg of Selank for ease of dosing.
- 4Slowly inject the BWFI into the Selank vial, aiming the stream at the glass wall rather than directly onto the powder.
- 5Gently swirl the vial to dissolve the peptide. Do not shake vigorously, as this can damage the peptide structure.
- 6Once fully dissolved and clear, the solution is ready for administration or storage.
Typically reconstituted with bacteriostatic water for injection (BWFI).
What to Expect
- Week 1: Initial reports often describe subtle reductions in anxiety, improved mood, and increased calmness.
- Week 2-4: More consistent reports of enhanced cognitive function, including improved focus and memory, along with sustained anxiolytic effects.
- Week 4-6: Peak effects are often noted, with researchers reporting significant improvements in stress resilience and overall well-being. Some may observe enhanced learning capabilities.
- Post-cycle: Benefits may persist for some time after the research cycle concludes, although individual responses vary.
Side Effects & Safety
| Effect | Frequency | Severity |
|---|---|---|
| Mild sedation at high doses | Uncommon | Mild |
| Nasal irritation | Uncommon | Mild |
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Open CalculatorPeptides discussed here are for research purposes only. Nothing on this page is medical advice. Always consult a qualified professional before making health decisions.