Orexin-A
ResearchA hypothalamic neuropeptide involved in wakefulness, appetite, and energy homeostasis. Deficiency causes narcolepsy. Researched for sleep disorders, cognitive enhancement, and metabolic effects.
SleepCognitive EnhancementMetabolic Health
Half Life
Short
Time to Results
Acute effects within hours
Administration
Nasal spray, IV
🐾 Griffin's Research Scorecard
Research Strength
Human Data
Animal Data
Long-Term Data
Beginner Friendly
Storage Difficulty
Injection FrequencyAs needed
Cost$$$
🐾 Griffin Says...
Orexin deficiency is literally what causes narcolepsy - people with narcolepsy have lost their orexin-producing neurons. Research into orexin supplementation is directly relevant to one of the most debilitating sleep disorders. Also interesting as a wakefulness promoter.
Benefits
- Wakefulness promotion
- Cognitive performance improvement
- Appetite regulation
- Narcolepsy research
- Energy homeostasis
Best For
- Wakefulness research
- Narcolepsy research
- Sleep disorder research
- Cognitive research
Body Systems
Nervous SystemMetabolicEndocrine
Mechanisms of Action
- Orexin-1 and Orexin-2 receptor agonist
- Promotes norepinephrine, serotonin, dopamine release
- Stabilizes sleep-wake transitions
Side Effects
| Effect | Frequency | Severity |
|---|---|---|
| Limited safety data in humans | Unknown | Unknown |
| Potential cardiovascular stimulation | Theoretical | Mild |
Contraindications
Very limited data, caution with cardiovascular conditions
Peptides discussed here are for research purposes only. Nothing on this page is medical advice. Always consult a qualified professional before making health decisions.
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