Melanotan II
Human ResearchMelanotan II
A synthetic analog of alpha-MSH studied for skin tanning, sexual function, and appetite regulation. One of the most well-known research peptides for pigmentation.
Dose
0.25 mg - 1 mg
Route
SubQ injection
Cycle
Variable, typically 2-4 weeks for initial tanning, then ongoing for maintenance or as needed for other indications.
Storage
Refrigerated (2-8°C) away from light; can be stored frozen for longer periods (-20°C).
What is Melanotan II?
Melanotan II (MT-II) is a synthetic cyclic peptide analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). It is widely studied for its ability to induce melanogenesis, leading to skin pigmentation without exposure to ultraviolet (UV) radiation. Beyond its tanning effects, MT-II is also recognized for its impact on sexual function, particularly male erectile dysfunction, and its potential role in appetite suppression due to its non-selective agonism of various melanocortin receptors (MC1R, MC3R, MC4R, MC5R). Research often explores its mechanisms in stimulating melanocytes, influencing central nervous system pathways related to sexual arousal, and modulating metabolic processes.
Key Benefits
- Skin tanning without UV
- Increased libido
- Reduced appetite
- Potential erectile function improvement
Mechanism of Action
- Non-selective melanocortin receptor agonist
- Stimulates melanogenesis
- Activates MC4R for sexual effects
Best For
- Pigmentation research
- Sexual health research
Body Systems
🐾 Griffin Says...
Molecular Information
Molecular weight
1024.2 g/mol
Length
7
Type
Synthetic cyclic peptide analog
Amino acid sequence
Ac-Nle-cyclo[-Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Acetyl (Ac) at N-terminus, amide (NH2) at C-terminus, with a cyclic lactam bridge between Asp and Lys residues.
Pharmacokinetics
Time to peak
1-2 hours
Half-life
0.55 h
Time to clear
Approximately 2-3 hours
Hadley, M. E. (2009). Discovery of Melanotan-peptide hormones for tanning and sexual dysfunction. Journal of Dermatology, 36(11), 600-607.
Research Indications
Skin Pigmentation (Tanning)
Melanotan II is highly effective in stimulating melanogenesis, leading to darker skin pigmentation, often without the need for significant UV exposure. This effect is mediated primarily through MC1R activation.
Prevention of Sunburn (Photoprotection)
While inducing a tan, research suggests the increased melanin may offer some photoprotective benefits, reducing the incidence of sunburn, though it does not replace traditional sun protection.
Research Protocols
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Initial Tanning (Loading Phase) | 0.25 mg - 0.5 mg | Daily | Subcutaneous |
| Tanning Maintenance | 0.5 mg - 1 mg | 1-3 times per week | Subcutaneous |
| Erectile Dysfunction Research | 0.5 mg - 1 mg | Approximately 4-6 hours prior to desired effect, on an 'as needed' basis | Subcutaneous |
| Appetite Suppression Research | 0.25 mg - 0.5 mg | Daily, or before main meal | Subcutaneous |
| Assessing Tolerance (Initial Dose) | 0.1 mg - 0.25 mg | Once daily | Subcutaneous |
Researchers commonly adjust dosing and frequency based on individual response and desired outcomes, particularly regarding pigmentation and side effects. Lower starting doses are often discussed to assess tolerance.
Peptide Interactions
- Use Caution
Alcohol
Some research suggests that alcohol consumption might exacerbate side effects like nausea or flushing associated with Melanotan II.
- Compatible
UV Radiation (Sunlight/Tanning Beds)
While Melanotan II induces tanning without UV, moderate, controlled UV exposure is often discussed in research protocols to accelerate and deepen the tan, with appropriate caution.
- Avoid
Other melanocortin receptor agonists
Combining Melanotan II with other compounds acting on melanocortin receptors could lead to an unpredictable increase in side effects or an over-response due to cumulative agonism.
- Compatible
Antiemetics
In some research protocols, antiemetic agents have been considered to manage potential nausea side effects, especially during the initial phase of Melanotan II administration.
- Use Caution
MAOIs (Monoamine Oxidase Inhibitors)
Given Melanotan II's central nervous system effects, caution is advised when co-administering with MAOIs, as potential interactions with neurotransmitter systems have not been thoroughly studied.
How to Reconstitute
- 1Gather the lyophilized Melanotan II vial, a vial of bacteriostatic water for injection, a sterile syringe (e.g., 1mL U-100 insulin syringe), and alcohol wipes.
- 2Carefully remove the protective cap from both the Melanotan II vial and the bacteriostatic water vial, then wipe the rubber stoppers with alcohol wipes.
- 3Using the sterile syringe, draw the desired amount of bacteriostatic water (e.g., 1mL for 10mg vial) from its vial.
- 4Slowly inject the bacteriostatic water into the Melanotan II vial, aiming the stream down the side of the glass to avoid direct contact with the lyophilized powder.
- 5Do not shake the vial. Gently swirl the vial to aid dissolution. If particles remain, allow it to sit in the refrigerator for 15-30 minutes and swirl again.
- 6Once fully dissolved, the solution should be clear and free of particulate matter. Store the reconstituted solution in the refrigerator.
Bacteriostatic water for injection (BWFI) is generally preferred for reconstitution due to its preservative properties, which extend the shelf life of the reconstituted peptide.
What to Expect
- Weeks 1-2: Initial skin darkening may begin, often subtle. Nausea, flushing, and increased libido can be observed early on. Freckles or moles may darken faster.
- Weeks 3-4: More noticeable tanning typically develops. Side effects like nausea may subside or become more manageable.
- Weeks 5-8: Significant pigmentation becomes evident. Maintenance dosing may be considered to sustain the tan.
- Beyond 8 weeks: Continued use for maintenance of tan or to address other indications. Regular assessment of skin changes is important.
Side Effects & Safety
| Effect | Frequency | Severity |
|---|---|---|
| Nausea | Very Common | Mild |
| Facial flushing | Very Common | Mild |
| Spontaneous erections | Common (men) | Mild |
| Darkening of moles | Common | Moderate - monitor |
Ready to calculate your dose? Use Griffin's Peptide Calculator 🐾
Open CalculatorPeptides discussed here are for research purposes only. Nothing on this page is medical advice. Always consult a qualified professional before making health decisions.