BPC-157
Preclinical ResearchBody Protection Compound-157
A synthetic peptide fragment famous in research circles for tissue repair and gut health.
Dose
200-500 mcg
Route
Subcutaneous injection, Oral capsule
Cycle
4-8 weeks
Storage
Refrigerated (2-8°C) for up to 2 years, or freezer (-20°C) for longer storage.
What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic fifteen-amino acid peptide derived from a human gastric protein. It has gained significant attention in research for its robust regenerative and protective properties across various tissue types. Its mechanisms of action are believed to involve the upregulation of growth hormone receptors, promotion of angiogenesis (new blood vessel formation), anti-inflammatory effects, and modulation of various growth factors and signaling pathways involved in tissue repair and healing. Research frequently explores its potential in gastrointestinal integrity, musculoskeletal injury recovery, and neuroprotection.
Key Benefits
- Tendon and ligament repair
- Gut lining support
- Reduced inflammation
Mechanism of Action
- Upregulates growth hormone receptors
- Promotes angiogenesis
Best For
- Recovery from injury
- Gut issues
- Post-workout repair
Body Systems
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Molecular Information
Molecular weight
1419.535 g/mol
Length
15 amino acids
Type
Synthetic Peptide
Amino acid sequence
Gly-Glu-Pro-Pro-Pro-Ala-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-L-leucyl-L-valine
Pharmacokinetics
Time to peak
1-2 hours (subcutaneous)
Half-life
4 h
Time to clear
Approximately 1-2 days based on half-life (systemic activity).
Systemic half-life data is primarily from animal models, human data is less extensively published but generally consistent with rapid clearance.
Research Indications
Tendon and Ligament Repair
Promotes the healing of various soft tissue injuries, including tendon-to-bone healing and ligament repair, often attributed to increased growth factor expression and collagen synthesis.
Muscle and Bone Regeneration
Research suggests accelerating muscle and bone repair processes, including fracture healing and recovery from muscle tears.
Research Protocols
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| General Tissue Repair / Systemic Effects | 200-300 mcg | Once daily | Subcutaneous injection (abdominal region) |
| Targeted Localized Injury Healing (e.g., tendon, muscle) | 100-250 mcg | Once daily (or split into twice daily) | Subcutaneous or Intramuscular injection near the injury site |
| Gastrointestinal Health / Oral Delivery | 250-500 mcg | Once or twice daily | Oral (capsule or solution) |
| Enhanced Healing for More Severe Injuries | 400-500 mcg | Once daily (or split into twice daily) | Subcutaneous injection (abdominal or targeted) |
| Maintenance / Protective Protocol | 100-200 mcg | Once daily | Subcutaneous injection |
For systemic effects, daily dosing is common. For localized injuries, administration near the injury site is frequently discussed in research protocols.
Peptide Interactions
- Compatible
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
While both aim to reduce inflammation, BPC-157's mechanism is distinct and often complementary, potentially mitigating some of the GI side effects of NSAIDs. No direct negative interaction reported.
- Synergistic
Growth Hormone Secretagogues (e.g., Ipamorelin, GHRP-2)
The pro-healing effects of BPC-157 may be enhanced when combined with compounds that boost growth hormone and IGF-1 levels, potentially leading to accelerated tissue repair.
- Monitor Combination
Corticosteroids
Corticosteroids can impair healing, which BPC-157 aims to enhance. Research suggests BPC-157 may counteract some of the negative healing effects of corticosteroids, but caution is advised due to their opposing actions.
- Use Caution
Blood Thinners / Anticoagulants
Due to BPC-157's pro-angiogenic effects, there's a theoretical, though unconfirmed, potential for altered bleeding or clotting. Monitoring is advised, especially with high doses.
- Compatible
Immunosuppressants
No direct interactions reported. BPC-157 has immunomodulatory properties, but typically in a pro-healing context rather than systemic immunosuppression.
How to Reconstitute
- 1Gather lyophilized BPC-157 vial, bacteriostatic water (BW), sterile syringes, and alcohol wipes.
- 2Clean the rubber stopper of both the BPC-157 vial and the BW vial with alcohol wipes.
- 3Draw the desired amount of bacteriostatic water (e.g., 1-2 mL) into a sterile syringe.
- 4Slowly inject the BW into the BPC-157 vial, allowing it to run down the inside wall. Do not inject directly onto the powder.
- 5Remove the syringe and gently swirl the vial (do not shake) to allow the powder to fully dissolve. This may take a few minutes.
- 6Once fully dissolved, the solution should be clear. Store immediately in the refrigerator.
Always use bacteriostatic water for reconstitution to extend shelf life. Avoid shaking vigorously to prevent denaturing the peptide.
What to Expect
- Weeks 1-2: Initial observations may include reduced discomfort, especially in gut-related issues or acute injuries.
- Weeks 2-4: More noticeable improvements in healing processes, such as reduced inflammation and improved recovery from exercise or injury.
- Weeks 4-6: Continued enhancement of tissue repair, potentially observing improved strength or function in affected areas. Gut healing effects may become more pronounced.
- Weeks 6-8: Peak effects on tissue regeneration and protective benefits. Some researchers discuss considering a cycle break at this point.
Side Effects & Safety
| Effect | Frequency | Severity |
|---|---|---|
| Injection site irritation | Uncommon | Mild |
| Mild fatigue | Rare | Mild |
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Open CalculatorPeptides discussed here are for research purposes only. Nothing on this page is medical advice. Always consult a qualified professional before making health decisions.